2 East 78th Street is a 26'-wide single-family house currently used as headquarters of a nonprofit organization. The property has been renovated to a high standard by Keenen/Riley. Permitted uses within the R10 zoning district include residential, live/work, community facility (including nonprofit, educational, medical) and governmental. The building measures 2,626 square feet on four levels. East 78th Street from Fifth Avenue to Madison Avenue is an exceptional block featuring several large mansions including the James B. Duke Mansion at 1 East 78th Street (now home to the NYU Institute of Fine Arts) and the Stuyvesant Fish Mansion at 25 East 78th Street (now home to Bloomberg Philanthropies). Property is currently used by the owner as a foundation office.